Antonio Cirino was born in Italy and came to the United States as a child of three. He attended the Rhode Island School of Design from 1904-1909 and later taught there. He also studied art in Italy and was a pupil of Arthur Wesley Dow. In the 1920s, he moved to Rockport, Massachusetts, living there in the summers and in Providence, Rhode Island the remainder of the year. He, along with Aldro Hibbard, was a founding member of the Rockport Art Association, of which he later became the president. Cirino became an active member of the Salmagundi Club of New York City in 1926 and showed there into the 1980s.
Upon his death, the Rockport Art Association became the recipient of his estate which became the cornerstone of their growing collection.